Introduction of drugs puts an evolutionary pressure on viruses and makes the viral proteins evolve. On the other hand, the change in the protein structure should be compatible with the protein function. The degree of the protein sequence conservativity is thus a measure of the structural importance of a particular region on the protein surface. Certain binding sites are evolving and mutate... moreIntroduction of drugs puts an evolutionary pressure on viruses and makes the viral proteins evolve. On the other hand, the change in the protein structure should be compatible with the protein function. The degree of the protein sequence conservativity is thus a measure of the structural importance of a particular region on the protein surface. Certain binding sites are evolving and mutate often, certain are not. Finding the most conservative fractions of a target protein sequence can help identify important and druggable binding sites for inhibitors search, find drugs with the least potential for drug resistance development. view page